Publications

Zheng M, Ramsay AJ, Robichaux MB, Kliment C, Crowe C, Rapaka RR, Steele C, McAllister F, Shellito JE, Marrero L, Schwarzenberger P, Zhong Q, Kolls JK. CD4+ T cell-independent DNA vaccination against opportunistic infections. JCI. 2005; 115(12):3536-44. PMID: 16308571

Kliment CR, Tobolewski JM, Manni ML, Tan RJ, Enghild J, Oury TD. Extracellular superoxide dismutase protects against matrix degradation of heparan sulfate in the lung. Antioxidants & redox signaling. 2008; 10(2):261-8. PMID: 17961072

Myllärniemi M, Lindholm P, Ryynänen MJ, Kliment CR, Salmenkivi K, Keski-Oja J, Kinnula VL, Oury TD, Koli K. Gremlin-mediated decrease in bone morphogenetic protein signaling promotes pulmonary fibrosis. American journal of respiratory and critical care medicine. 2008; 177(3):321-9. PMID: 17975199

Carraway MS, Suliman HB, Kliment C, Welty-Wolf KE, Oury TD, Piantadosi CA. Mitochondrial biogenesis in the pulmonary vasculature during inhalational lung injury and fibrosis. Antioxidants & redox signaling. 2008; 10(2):269-75. PMID: 17999632

Kliment CR, Clemens K, Oury TD. North american erionite-associated mesothelioma with pleural plaques and pulmonary fibrosis: a case report. International journal of clinical and experimental pathology. 2009; 2(4):407-10. PMID: 19158938

Kliment CR, Englert JM, Gochuico BR, Yu G, Kaminski N, Rosas I, Oury TD. Oxidative stress alters syndecan-1 distribution in lungs with pulmonary fibrosis. JBC. 2009; 284(6):3537-45. PMID: 19073610

Kliment CR, Suliman HB, Tobolewski JM, Reynolds CM, Day BJ, Zhu X, McTiernan CF, McGaffin KR, Piantadosi CA, Oury TD. Extracellular superoxide dismutase regulates cardiac function and fibrosis. Journal of molecular and cellular cardiology. 2009; 47(5):730-42. PMID: 19695260

Houghton AM, Rzymkiewicz DM, Ji H, Gregory AD, Egea EE, Metz HE, Stolz DB, Land SR, Marconcini LA, Kliment CR, Jenkins KM, Beaulieu KA, Mouded M, Frank SJ, Wong KK, Shapiro SD. Neutrophil elastase-mediated degradation of IRS-1 accelerates lung tumor growth. Nature medicine. 2010; 16(2):219-23. PMID: 20081861

Kliment CR, Oury TD. Oxidative stress, extracellular matrix targets, and idiopathic pulmonary fibrosis. Free radical biology & medicine. 2010;49(5):707-17. PMID: 20452419

Englert JM, Kliment CR, Ramsgaard L, Milutinovic PS, Crum L, Tobolewski JM, Oury TD. Paradoxical function for the receptor for advanced glycation end products in mouse models of pulmonary fibrosis. Int J Clin Exp Pathol. 2011; 4(3):241-54.

Kliment CR, Englert JM, Crum LP, Oury TD. A novel method for accurate collagen and biochemical assessment of pulmonary tissue utilizing one animal. International journal of clinical and experimental pathology. 2011; 4(4):349-55. PMID: 21577320

Kliment CR, Oury TD. Extracellular superoxide dismutase protects cardiovascular syndecan-1 from oxidative shedding. Free radical biology & medicine. 2011; 50(9):1075-80. PMID: 21334435

Gregory AD*, Kliment CR*, Metz HE, Kim KH, Kargl J, Agostini BA, Crum LT, Oczypok EA, Oury TA, Houghton AM. Neutrophil elastase promotes myofibroblast differentiation in lung fibrosis. Journal of leukocyte biology. 2015; 98(2):143-52. PMID: 25743626 (*Authors contributed equally to the work)

Kliment CR, Araki T, Doyle TJ, Gao W, Dupuis J, Latourelle JC, Zazueta OE, Fernandez IE, Nishino M, Okajima Y, Ross JC, Estépar RS, Diaz AA, Lederer DJ, Schwartz DA, Silverman EK, Rosas IO, Washko GR, O’Connor GT, Hatabu H, Hunninghake GM. A comparison of visual and quantitative methods to identify interstitial lung abnormalities. BMC pulmonary medicine. 2015; 15:134. PMID: 26514822

O’Connell OJ, Almeida FA, Simoff MJ, Yarmus L, Lazarus R, Young B, Chen Y, Semaan R, Saettele TM, Cicenia J, Bedi H, Kliment CR, Li L, Sethi S, Diaz-Mendoza J, Feller-Kopman D, Song J, Gildea T, Lee H, Grosu HB, Machuzak M, Rodriguez-Vial M, Eapen GA, Jimenez CA, Casal RF, Ost DE. A Prediction Model to Help with the Assessment of Adenopathy in Lung Cancer (HAL). Am J Respir Crit Care Med. 2016 Dec 21. [Epub ahead of print] PMID: 28002683.

Suresh K, Servinsky L, Jiang H, Bigham Z, Yun X, Kliment C, Huetsch J, Damarla M, Shimoda LA.Reactive oxygen species induced Ca₂₊influx via TRPV4 and microvascular endothelial dysfunction in the SU5416/hypoxia model of pulmonary arterial hypertension. Am J Physiol Lung Cell Mol Physiol. 2018 May 1;314(5):L893-L907.

Suresh K, Servinsky L, Jiang H, Kliment, CR, et al. Regulation of mitochondrial fragmentation in microvascular endothelial cells isolated from the SU5416/hypoxia model of pulmonary arterial hypertension.Am J Physiol Lung Cell Mol Physiol. 2019;317(5):L639–L652. doi:10.1152/ajplung.00396.2018

Kliment, CR, Barbash, IJ, Brenner, JS, Chandra, D, Courtright, C, Gauthier, MC, Robinson, KM, Scheunemann, LP, Shah, F, Christie, JD, Morris, A. COVID-19 and the Early Career Physician Scientist: Fostering Resilience Beyond the Pandemic. ATS Scholar, 2020, Oct 23;2(1):19-28. https://doi.org/10.34197/ats-scholar.2020-0104PS. PMID: 33870320

Kliment CR, Nguyen JMK, Kaltreider MJ, Lu Y, Claypool SM, Radder JE, Sciurba FC, Zhang Y, Gregory AD, Iglesias PA, Sidhaye VK, Robinson DN. Adenine Nucleotide Translocase regulates airway epithelial metabolism, surface hydration, and ciliary function. J Cell Sci. 2021 Feb 25; 134(4);jcs.257162. PMID:33526710

Ghosh-Choudry, S, Carleton, N, Flynne, J, Kliment, CR. Strategies for Achieving Gender Equity and Work-Life Integration in Physician Scientist Training. Academic Medicine, July 20, 2021, PMID: 34292189

Ghosh-Choudhary S, Carleton N, Nouraie S, Kliment CR, Steinman RA. Predoctoral MD-PhD grants as indicators of future NIH funding success. JCI insight. 2022 March 22;7(6):e155688. PMID:35315356

Florentin, J, Scott P O’neil, SP, Vasamsetti, SB, Ohayon, LL, Arunkumar, A, Ghosh, S, Boatz, JC, Sui, J, Kliment, CR, Chan, SY, Dutta, P. VEGF receptor 1 promotes hypoxia-induced hematopoietic progenitor proliferation and differentiation. Frontiers in Immunology. 2022 (In Press).

Kliment, CR^*, Gosen, R. Chymase-1 – a “MAST”er switch in COPD? European Respiratory Journal. 60: 2201356; DOI: 10.1183/13993003.01356-2022. ^*Corresponding

Boatz, JC*, Sui, J*, Hu, Q, Li, X, Zhang, X, Königshoff, M, Kliment, CR. 2022. Loss of ANT1 IncreasesFibrosis and Epithelial Cell Senescence in Idiopathic Pulmonary Fibrosis. bioRxiv doi: 10.1101/2019.12.11.123456.*Co-first authors

Sui, J*, Boatz, JC*, Hu, Q, Li, X, Zhang, X, Königshoff, M, Kliment, CR. Loss of ANT1 IncreasesFibrosis and Epithelial Cell Senescence in Idiopathic Pulmonary Fibrosis. Am J Respir Cell Mol Bio *Co-first authors. 2023 Nov; PMID: 37487137.

Risbano, MG, Kliment, CR, Dunlap, DG, Koch, C, Campedelli, L, Yoney, K, Nouraie, M, Sciurba, F, Morris, A. Invasive Cardiopulmonary Exercise Testing Identifies Distinct Physiologic Endotypes in Post-acute Sequelae of SARS-CoV-2 Infection. Chest Pulmonary (Accepted, In Press)

Ware SA*, Kliment CR*, Giordano L*, Redding KM, Rumsey WL, Bates S, Zhang Y, Sciurba FC, Nouraie SM, Kaufman BA. Cell-free DNA levels associate with COPD exacerbations and mortality. Respir Res. 2024 Jan. PMID: 38238743. *Co-first authors

Kliment CR, Oury TD. Studies on Respiratory Disorders XII ed. Ganguly NK, Jindal SK, Barnes PJ, Pawankar R, editors. Humana Press: Springer; 2014. Chapter: Pulmonary Fibrosis and Oxidative Stress; p.163-190. 394p.

Kliment CR, Englert JM, Oury TD. Pathology of Asbestosis-related Diseases. Elsevier; 2014. Chapter: Animal models of Asbestosis.

Kliment CR and Campbell, E. Chapter on Aging of the Respiratory System, Fishman’s Textbook on Pulmonary Disease and Disorder, 6^th Edition, McGraw Hill Publishing 2021 (In Press).

Sui, J, Boatz, JC, Kaltreider, MJ, Gregory, A, Shapiro, SD, Kliment,CR. Single-Cell RNA Sequencing of a Mouse COPD Model Identifies Aberrant Macrophage Responses Critical for Lung Protection due to Adenine Nucleotide Translocase 1 (ant1) Deficiency. American Thoracic Society International Conference. San Diego, CA; AJRCCM 2021; Vol 203. Poster discussion session

Boatz, JC, Kaltrieder, MJ, Sui, J, Sciurba, FC, Zhang, Y, Kliment, CR. Loss of Mitochondrial Protein Adenine Nucleotide Translocase 1 Induces Cellular Senescence and Aggravates Bleomycin Induced Pulmonary Fibrosis in a Mouse Model. American Thoracic Society International Conference; AJRCCM 2021; Vol 203. Poster discussion session

Boatz, JC, Kaltrieder, MJ, Gregory, A, Sciurba, FC, Zhang, Y, Chandra, D, Shapiro, SD, Kliment, CR. Mitochondrial adenine nucleotide translocases (ANT) regulates cellular senescence in chronic obstructive pulmonary disease. American Thoracic Society International Conference, AJRCCM, 2020; vol 201. Poster discussion session.

Boatz, JC, Kaltrieder, MJ, Sciurba, FC, Zhang, Y, Kliment, CR. Loss of mitochondrial Adenine Nucleotide Translocase worsens bleomycin-induced pulmonary fibrosis and inflammation. American Thoracic Society International Conference, AJRCCM, 2020; vol 201. Poster discussion session.

Kliment, CR , Nguyen, JM, Claypool, SM, Radder, JE, Sciurba, FC, Zhang, Y, Gregory, AD, Iglesias, PA, Sidhaye, VK, Shapiro, SD, and Robinson, DN. Mitochondrial Adenine Nucleotide Translocase influences ciliary function and airway homeostasis. American Thoracic Society International Conference, Dallas, TX, May 2019. Abstract/poster presentation.

Sui, J, Boatz, JC, Kaltreider, MJ, Gregory, A, Shapiro, SD, Kliment, CR. Single-Cell RNA Sequencing of a Mouse COPD Model Identifies Aberrant Macrophage Responses Critical for Lung Protection due to Adenine Nucleotide Translocase 1 (ant1) Deficiency. University of Pittsburgh School of Medicine Research Day. Pittsburgh, PA, April 2021. Oral presentation.

Boatz, JC, Kaltrieder, MJ, Sui, J, Sciurba, FC, Zhang, Y, Kliment, CR. Loss of Mitochondrial Protein Adenine Nucleotide Translocase 1 Induces Cellular Senescence and Aggravates Bleomycin Induced Pulmonary Fibrosis in a Mouse Model. University of Pittsburgh Department of Medicine Research Day. Pittsburgh, PA. April, 2021. Abstract/poster presentation.